Episode 26: Dr. Jessica Rose on Modified MRNA In Covid-19 Vaccines

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Hi everyone,

I’m delighted to have on molecular biologist and fellow freedom fighter

Jessica Rose

on the podcast today. In this conversation, we discuss a new Nature paper that highlights the potential problems with the modified mRNA used in the COVID-19 vaccines. They explain the process of mRNA and protein translation, as well as the role of codon optimization. The conversation delves into the implications of N1-methyl pseudouridine and frame shifting, which can lead to the production of unintended proteins. We also discuss the unpredictability of dosing and the need for further research to understand the potential risks associated with the modified mRNA vaccines. The conversation explores the implications of increasing GC content in mRNA vaccines and the potential complications it can cause. The concept of co-translational folding is also delineated, highlighting the complexity of protein production. The conversation then delves into the potential of the mRNA platform for various applications and the need for caution and regulatory processes.

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Takeaways

• The modified mRNA used in the COVID-19 vaccines can lead to frame shifting and the production of unintended proteins.

• Codon optimization plays a role in protein production, but it can also introduce potential problems.

• The use of N1-methyl pseudouridine in the mRNA vaccines may increase the risk of frame shifting.

• Further research is needed to understand the potential risks associated with the modified mRNA vaccines. Increasing GC content in mRNA vaccines can have implications and complications, such as ribosomal pausing and frame shifting.

• Co-translational folding is a complex process that occurs during protein production.

• The mRNA platform has potential for various applications, but careful consideration and regulatory processes are necessary.

• The complexity of the human body and the potential for unintended consequences should be taken into account when developing mRNA vaccines.

• Safety and efficacy should be thoroughly evaluated before approving mRNA vaccines for widespread use.

Chapters

00:00 Introduction and Background

07:05 Discussion on COVID Work

08:34 Introduction to the Nature Paper

09:01 mRNA and Protein Translation

13:25 Modified mRNA and Protein Production

29:24 N1-methyl Pseudouridine and Frame Shifting

36:05 Discussion on the Nature Paper

45:37 Implications and Unknowns

52:04 Predictability and Dosing

53:01 Codon Optimization and Slippery Sequences

54:56 Codon Optimization and Protein Production

55:54 Implications of Increasing GC Content

56:49 Ribosomal Pausing and Frame Shifting

59:08 Co-Translational Folding

01:00:06 The Potential of the mRNA Platform

01:01:31 The Complexity of the Human Body

01:03:17 Safety and Regulatory Considerations

01:05:40 Challenges of Coding Different Proteins

01:07:01 The Need for Regulatory Processes

01:09:21 Takeaways and Implications

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