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I’m delighted to have on molecular biologist and fellow freedom fighteron the podcast today. In this conversation, we discuss a new Nature paper that highlights the potential problems with the modified mRNA used in the COVID-19 vaccines. They explain the process of mRNA and protein translation, as well as the role of codon optimization. The conversation delves into the implications of N1-methyl pseudouridine and frame shifting, which can lead to the production of unintended proteins. We also discuss the unpredictability of dosing and the need for further research to understand the potential risks associated with the modified mRNA vaccines. The conversation explores the implications of increasing GC content in mRNA vaccines and the potential complications it can cause. The concept of co-translational folding is also delineated, highlighting the complexity of protein production. The conversation then delves into the potential of the mRNA platform for various applications and the need for caution and regulatory processes.
The modified mRNA used in the COVID-19 vaccines can lead to frame shifting and the production of unintended proteins.
Codon optimization plays a role in protein production, but it can also introduce potential problems.
The use of N1-methyl pseudouridine in the mRNA vaccines may increase the risk of frame shifting.
Further research is needed to understand the potential risks associated with the modified mRNA vaccines. Increasing GC content in mRNA vaccines can have implications and complications, such as ribosomal pausing and frame shifting.
Co-translational folding is a complex process that occurs during protein production.
The mRNA platform has potential for various applications, but careful consideration and regulatory processes are necessary.
The complexity of the human body and the potential for unintended consequences should be taken into account when developing mRNA vaccines.
Safety and efficacy should be thoroughly evaluated before approving mRNA vaccines for widespread use.
00:00 Introduction and Background
07:05 Discussion on COVID Work
08:34 Introduction to the Nature Paper
09:01 mRNA and Protein Translation
13:25 Modified mRNA and Protein Production
29:24 N1-methyl Pseudouridine and Frame Shifting
36:05 Discussion on the Nature Paper
45:37 Implications and Unknowns
52:04 Predictability and Dosing
53:01 Codon Optimization and Slippery Sequences
54:56 Codon Optimization and Protein Production
55:54 Implications of Increasing GC Content
56:49 Ribosomal Pausing and Frame Shifting
59:08 Co-Translational Folding
01:00:06 The Potential of the mRNA Platform
01:01:31 The Complexity of the Human Body
01:03:17 Safety and Regulatory Considerations
01:05:40 Challenges of Coding Different Proteins
01:07:01 The Need for Regulatory Processes
01:09:21 Takeaways and Implications
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