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Adrian Gaty's avatar

Awesome! Please thank him for all his amazing work! Weird peer review question: many great scientific breakthroughs in history were so paradigm shifting they rendered the scientist’s peers irrelevant, and they certainly weren’t welcome by those peers initially. Doesn’t peer review retard scientific progress? Alt: does he believe science/medicine made more significant/impressive breakthroughs in the centuries before peer review, or the period after it was so rigorously adopted?

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Florida ER Doc's avatar

Hey Rav. How do we address the problem of Principal Investigator bias in clinical trials? As an example: In the original J & J adenovirus vector vaccine trial, a young man suffered a cerebral venous thrombus (VITT) after receiving the vaccine. This was deemed "not related to therapy" by the PI, and the vaccine was approved. As we all know, it was later withdrawn from the market because of the "rare" and "unforeseen" incidence of VITT (which it should be noted was 1/22,000 in the study group). There were incidences of PE's and DVT's that were similarly dismissed in the vaccine arm.

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